Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and diclofanac are the most commonly prescribed drugs for arthritis, inflammation, and cardiovascular protection. However, they cause gastrointestinal complications such as ulcers and erosions. The pathophysiology of these complications has mostly been ascribed to NSAID’s action on the cyclooxygenase (COX) inhibition and the subsequent prostaglandin (PG) deficiency. Here’s some Pharmacology mnemonics.
Beneficial effects of inhibition of prostaglandin synthesis by NSAIDs (remember of 5 A’s)
Analgesia
Antipyretic
Anti-inflammatory
Antithrombotic
Arteriosus (NSAIDs for closure of patent ductus arteriosus)
Side effects of NSAIDs (remember of nSAID):
Swelling
Allergy
Impaired renal function
Damage stomach wall (ulcer)
Contraindications to NSAIDs (remember of BARS)
Bleeding (peri-op, coagulopathy)
Asthma (10% of asthmatics are sensitive to non-steroidals)
Renal disease (hypovolaemia)
Stomach (peptic ulcer or gastritis). Can prescribe PPI for gastro-protection
NSAIDs-classification (remember of Painted By SOFIA).
P-propionic acid derivates
-pyrrolo derivates
-pyrazolon derivates
B-benzoxazocin derivates
S-salicylates:
O-oxicame derivates
F-fenamic acid derivates
I-indol derivates
A-aryl acetic acid and anthranilic acid derivates
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