🌹Amiodarone 🌹
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is generally considered the most effective antiarrhythmic agent, though its risk of toxicity increases with dosage and duration of treatment. The most serious toxicities include pulmonary fibrosis and hepatic failure.
🔸Similarities Between Amiodarone & Dronedarone:
Amiodarone and dronedarone have similar molecular structures, but because of the molecular differences and absence of iodine, dronedarone is free of most of amiodarone's organ toxicity with only rare cases of liver toxicity. FDA instructions indicate that liver function tests should be repeated after initiation of dronedarone.
🔅Side Effects:
🔹Nausea is frequent
🔹Bradycardia is common
🔹Thyroid dysfunction is common, with hypothyroidism being more common than hyperthyroidism
🔹Photosensitivity and bluish discoloration when exposed to direct sunlight
🔎Notes"
Many clinicians follow pulmonary function tests (PFTs), thyroid function tests, liver function tests at baseline and every 3-6 months (12 months for PFTs). The diffusing capacity is the most sensitive and specific change in the PFTs to detect pulmonary toxicity. A chest CT is often used when PFTs are abnormal.
▪️▪️▪️▪️▪️▪️▪️
is generally considered the most effective antiarrhythmic agent, though its risk of toxicity increases with dosage and duration of treatment. The most serious toxicities include pulmonary fibrosis and hepatic failure.
🔸Similarities Between Amiodarone & Dronedarone:
Amiodarone and dronedarone have similar molecular structures, but because of the molecular differences and absence of iodine, dronedarone is free of most of amiodarone's organ toxicity with only rare cases of liver toxicity. FDA instructions indicate that liver function tests should be repeated after initiation of dronedarone.
🔅Side Effects:
🔹Nausea is frequent
🔹Bradycardia is common
🔹Thyroid dysfunction is common, with hypothyroidism being more common than hyperthyroidism
🔹Photosensitivity and bluish discoloration when exposed to direct sunlight
🔎Notes"
Many clinicians follow pulmonary function tests (PFTs), thyroid function tests, liver function tests at baseline and every 3-6 months (12 months for PFTs). The diffusing capacity is the most sensitive and specific change in the PFTs to detect pulmonary toxicity. A chest CT is often used when PFTs are abnormal.
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