1.General Principles:
CYP450 inducers:
"Smoking and Drinking in BARB's CAR RIFS her PHEN" >>> smoking(benzopyrines), chronic alcoholism, barbiturates, carbamazepine, rifampin, phenytoin
CYP450 inhibitors:
"CoKE and Grapefruit juice with your PI" >>> Cimetidine, Ketoconazole, Erythromycin, grapefruit juice, protease inhibitors(ritonavir, indinavir etc)
Side effect profile of macrolides(from least to the most, go in alphabetical order)>>> ACE>>> azithromycin, calithromycin, erythromycin
Lupus causing drugs: "it's HIP to have lupus" >>> Hydralazine, Isoniazid, Procainamide
Drugs eliminated by zero order kinetics: "zero PEAs for me" >>> Phenytoin Ethanol Aspirin
Irreversible inhibitors
(non competitive antagonist drugs): phenoxybenzamine(a1), allopurinol(XO), Aspirin(COX1 and2), PPIs(HKatpase)
2.ANS:
(b)ethanechol for (b)owels and (b)ladder>>> tx: ileus/post op, neurogenic urinary retention
Meperidine(the only opiate not causing miosis due to anti muscarinic effects)
Adrenoceptor sensitivity(from most to least: reverse alphabetical order)>>> Dopamine r, beta r, alpha receptors
(p)henyl(e)phrine: for (p)rostate and (e)yes, also a nasal decongestant!
Drugs causing flushing:
Vasodilators
Niacin(PG mediated)>>> pretreat with aspirin
Due to histamine release: vancomycin(red man syndrome), morphine(^ICP in head trauma, so avoid), amphotericinB(pretreat with antihistamine)
(n)orepinephrine: (n)ever lowers bp
-olol: beta blockers only
-ilol/alol
beta blockers+some other blockade activity
(labetalol, carvedilol, sotalol)
3. CVS and Renal:
Nephrogenic DI(doc: thiazides, if caused by Li+: amiodarone)
aliski(ren)>>> blockes (ren)in
Drugs causing gingival hyperplasia: -dipines(Ca channel bl), phenytoin, cyclosporine
Drugs of HTN>>> A B C Ds of htn: ACEi/Arb, Beta bl, Ca ch bl, Diuretics
Drugs improving survival in CHF: are either sympatholytics(beta bl) or inhibit aldosterone pathway(acei, arb, spironolactone)
4.CNS:
Drugs with disulfiram like effects: disulfiram, mertonidazole, cefoperazone, cefotetan, chloramphenicol, griesofulvin(avoid alcohol)
"Azoles" that are not antifungal: aripiprazole, omeprazole, pantoprazole, metronidazole etc(look for -conazoles in antifungals)
Benzodiazepines: "-lam" and "-pam"
DOC for syndromes causing hyperthermia:
Malignant hyperthermia: dantrolene
Neuroleptic malignant synd: dantrolene
Serotonin synd: cyproheptadine
5. Antimicrobials:
2nd gen ceph: "it's a FACt that i'm a FOXy, FURy man" >>> cefaclor, cefoxitin, cefuroxime
3rd gen ceph: "either AXe it or FIX it" >>> ceftriAXone, cefotAXime, ceFIXime
"tets for ticks">>> tetracycline used for tick borne diseases(rickettsia, lyme disease etc)
(M)acrolides: mm-mm: for Mycoplasma, Mycobacterium avium- Motilin(receptor stimulated) Methylation(of binding side confers resistance)
Metronidazole spectrum: "GET BaC on the metro G" >>> Giardia, Entamoeba, Trichomonas, Bacteroides, Clostridium, Gardnerella
Key diseases and their doc:
Syphilis: benzathine pen G
Gonorrhea: ceftriaxone
Chlamydia: azithromycin or doxycycline
Trichomonas: metro
Bacterial vaginosis: metro
UTI/cystitis/prostatitis: TMP/SMX or cipro
"-avir" for "a"ids "vir"us
"- ivir" for "i"nfluenza "vir"us
"-ovir" for "o"mg herpes "vir"us
Ral(teg)ravir: in(teg)rase inhibitor
6. Inflammation:
Microtubule inhibitors: colchicine, vincristine, vinblastine, paclitaxel, griseofulvin
7. Blood
Factor Xa inhibitors "ban" "Xa": -xabans
Ab(cix)imab>>> 2x3=6>>> bl gp(2)b(3)a---Ab(6)imab
8. Endocrine
Am(iod)arone>>> has iodine with thyroid symptoms(either hyper or hypo)
9. Anticancer:
Bleomycin>>> "blow"mycin>>> pulmonary se(fibrosis)
Doxirubicin and other" rubicins">>> side e on "ruby"(red) heart
10. Immunopharm:
Tras(tu)zumab>>> tras(2)zumab, blocks erb b(2) for breast(2) cancer
Ce(tux)imab: can wear 1 tux at a time: erb b1 antagonist>>> for head and neck cancers(head nd neck stick out when wearing a tux)
Good luck👍
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